Pneumolysin: stimulating protection
نویسندگان
چکیده
منابع مشابه
Protection against bacteremic pneumococcal infection by antibody to pneumolysin.
Pneumolysin is an important virulence factor of Streptococcus pneumoniae. This study examined the hypothesis that human antibody to pneumolysin provides protection against pneumococcal infection. At the time of hospital admission, patients with nonbacteremic pneumococcal pneumonia had higher levels of serum anti-pneumolysin IgG than did patients with bacteremic pneumococcal pneumonia or uninfec...
متن کاملProtection from Streptococcus pneumoniae keratitis by passive immunization with pneumolysin antiserum.
PURPOSE To determine whether passive immunization with pneumolysin antiserum can reduce corneal damage associated with pneumococcal keratitis. METHODS New Zealand White rabbits were intrastromally injected with Streptococcus pneumoniae and then passively immunized with control serum, antiserum against heat-inactivated pneumolysin (HI-PLY), or antiserum against cytotoxin-negative pneumolysin (...
متن کاملProtection against pneumococcal pneumonia in mice by monoclonal antibodies to pneumolysin.
Pneumolysin (PLY) is an important virulence factor of Streptococcus pneumoniae. We examined the ability of three murine monoclonal antibodies (MAbs) to PLY (PLY-4, PLY-5, and PLY-7) to affect the course of pneumococcal pneumonia in mice. The intravenous administration of antibodies PLY-4 and PLY-7 protected the mice from the lethal effect of the purified toxin. Mice treated with PLY-4 before in...
متن کاملProtection against Streptococcus pneumoniae elicited by immunization with pneumolysin and CbpA.
The need for the development of cheap and effective vaccines against pneumococcal disease has necessitated the evaluation of common virulence-associated proteins of Streptococcus pneumoniae as potential vaccine antigens. In this study, we examined the capacity of active immunization with a genetic toxoid derivative of pneumolysin (PdB) and/or a fragment of choline binding protein A (CbpA; also ...
متن کاملPhysical behavior of pneumolysin.
Pneumolysin behaved as an acidic protein having an isoelectric pH of 4.9, a molecular weight of approximately 63,000, and a sedimentation coefficient of approximately 4.3.
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ژورنال
عنوان ژورنال: Nature Reviews Microbiology
سال: 2010
ISSN: 1740-1526,1740-1534
DOI: 10.1038/nrmicro2497